Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease
Journal Title: Annals of Hepatology - Year 2014, Vol 13, Issue 5
Abstract
Non-alcoholic fatty liver disease (NAFLD) is considered to be a manifestation of liver metabolic damage and is related to insulin resistance and genetic susceptibility. Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) pathways as a result of lipopolysaccharide (LPS) recognition by Toll-like receptor 4 (TLR4). Simultaneously, the activation of NF-κB, as mediated by oxidative and endoplasmic reticulum (ER) stress and free fatty acid (FFA) or free cholesterol (FC) crystal formation, heavily relies on NF-κB regulatory factors and TLR4. Additionally, the imbalance of certain pro-inflammatory cytokines and chemokines released by innate immunity is deemed to promote the steatosis of hepatocytes. In conclusion, this review indicates that the inflammatory and oxidative stress of KCs play a significant role in the development of NAFLD.
Authors and Affiliations
Zhang Wenfeng, Wu Yakun, Mu Di, Gong Jianping, Huang Chun
Keywords
Related Articles
- EP ID EP78431
- DOI -
- Views 120
- Downloads 0
Contribution on the topic of hypovitaminosis D in chronic hepatitis C
Actinomycotic liver abscess: A rare complication of colonic diverticular disease
We present the first case of hepatic actinomycosis requiring both medical and surgical intervention due to liver dissemination from a primary colonic abscess. A 52-year-old white male had a computerised (CT) abdominal sc...
Review of the neurological manifestations of hepatitis E infection
Hepatitis E (HEV) is a common infection worldwide and is an emerging disease in developed countries. The presence of extra-hepatic manifestation of HEV infection is important to bear in mind so that the diagnosis is not...
Mycophenolate mofetil in liver transplant patients with calcineurin-inhibitor-induced renal impairment
Background: Calcineurin inhibitors (CNIs) provide effective immunosuppression after orthotopic liver transplantation (OLTx), but the associated nephrotoxicity can cause substantial morbidity and mortality among transplan...
Lipid-bound sialic acid (LSA) in liver diseases of different etiologies
Objective. There are evidences that the changes in glycosylation and sialylation of proteins and lipids play an important role in the pathogenesis and progression of various liver diseases. The aim of this study was to e...