Lectin-like oxidized low density lipoprotein receptor 1(LOX-1) levels and endothelial dysfunction in patients with primary essential hyperhidrosis
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 4
Abstract
Objective: Primary essential hyperhidrosis (PEH) is a disorder characterized by excessive sweating of palms, soles and axilla. Although its etiology was not fully understand, increased activity of the autonomic nervous system may play a role in the pathogenesis of PEH. In the study we aimed to investigate flow mediated dilatation and lectin like oxide LDL receptor 1 (LOX-1) levels as an indicator of endothelial dysfunction in patient with PEH. Methods: Thirty-three PEH patients diagnosed with starch-iodine test and age- and sex-matched 19 healthy controls were included in the study. Flow-mediated dilatation was performed by ultrasonographical measurement of brachial artery. Serum LOX-1 levels were analyzed with Enzyme-Linked Immuno-Sorbent Assay (ELISA) kit. Results: Brachial artery FMD diameters and post-nitrate dilatation diameters were not different between patients and the controls. There was no difference between patient and control groups when compared for LOX-1 levels. Conclusion: Larger studies are needed to understand, indeed, whether excessive hyperhidrosis in PEH is only a peripheral excessive response to normal sympathetic activity or a systemic sympathetic hyperactivity with cardiovascular effects, which is disguised by compensatory mechanisms, such as nitric oxide (NO). Key words: endothelial dysfunction, flow mediated dilatation, lectin like oxidized low density lipoprotein receptor 1, primary essential hyperhidrosis
Authors and Affiliations
Emine Rifaioglu, Gamze Erfan, Seval Kaçar, Savaş Güzel, Şeref Alpsoy, Mustafa Kulaç, Şemsettin Karaca, Bilge Şen, Özlem Ekiz, Nihat Şen
Keywords
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- EP ID EP136235
- DOI 10.5798/diclemedj.0921.2013.04.0327
- Views 95
- Downloads 0
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