Lipid Profile In Thalassemia Patients Common In Eastern India And It’s Correlation With Erythroid Bone Marrow Activity
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Introduction Lipid abnormalities, including low levels of all fractions of serum lipids have been repeatedly reported in all phenotypes of Beta- thalassemia patients. In the present study, the low lipid profile of various groups of thalassemia patients have been correlated with erythroid bone marrow activity. Aims and objectives The main aim of this cross sectional study is to evaluate the lipid profile in thalassemia patients common in Eastern India and its correlation with erythroid bone marrow activity. Materials and methods The study was conducted in the Department of General Medicine, Calcutta National Medical College And Hospital (CNMCH), Kolkata, India. The study population consisted of hundred Beta -thalassemia patients admitted in CNMCH. The period of study was one year and consisted mostly of E-Beta thalassemia patients(61%). Results Results proved that the higher erythroid bone marrow activity with the enhanced cholesterol consumption could be the dominant mechanism implicated in the lipid abnormalities of thalassemia patients. Conclusion The present study showed that hypolipidemia and erythroid hyperplasia was present in all groups of Betathalassemia patients. The extent of hypolipidemia and erythroid hyperplasia were most pronounced in E-Beta thalassemia patients and the abovementioned correlation was unrelated to hemoglobin levels and S.G.P.T(as a marker of liver injury).Future studies are required to compare the cardiovascular morbidity and mortality among different groups of Beta- thalassemia patients and to interprete the effect of hypolipidemia in them.
Authors and Affiliations
Maitra Somnath
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