Lizinopril Monotherapy and Sensitivity of the Baroreflex in Patients with Hypertension
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Under supervision, there were 9 female patients with primary arterial hypertension aged 51.6±5.3 years. During the month of observation, all patients took a stable dose of the lisinopril: 7 patients – 10 mg per day (twice daily for 5 mg), 2 patients - 5 mg per day. In the beginning and in the dynamics of treatment (weekly), the sensitivity of the arterial baroreflex (BRS) was recorded. In patients with PAH, in comparison with physically healthy persons of the same age, there is a significant decrease in BRS in the low-frequency and high-frequency bands with spontaneous breathing, which, however, responds well to the controlled breathing test. After a week of monotherapy with a lysinopril, there is a significant increase in BRSLF and BRSHF in spontaneous breathing and a significant increase in these parameters with controlled breathing. From the 2nd week of monotherapy, stabilization of BRSLF with spontaneous respiration and reduction of the response to controlled respiration, which reaches a maximum after 3 weeks of treatment, is observed.
Authors and Affiliations
A. P. Romanchuk, V. A. Shtanko, I. S. Bekalo
Keywords
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- EP ID EP441059
- DOI 10.9790/0853-1801127479.
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