Locomotor Behaviour and Anxiety in the Open Field and Light/Dark Box in CD1 Mice Treated with Aspirin, Cataflam and Ethanolic Extract of Cannabis sativa
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 6, Issue 6
Abstract
Aims: To study the effects of cataflam, aspirin and the ethanolic extract of Cannabis sativa on nociception in CD1 albino mice of both sexes. Methods: Twenty (20) albino mice were divided into four (4) groups of five (5) each. The control group (group 1) received normal saline orally. Meanwhile groups 2-4 received p.o. cataflam (1.5 mg/kg), aspirin (13.5mg/kg) and Cannabis sativa (10 mg/kg) respectively. All four (4) groups were given access to normal mice chow and water ad libitum. The Open field apparatus and the light/dark box were used to measure locomotor/exploratory behaviour and anxiety. Results: There was a significant (p=0.05) reduction in the frequencies of rearing, walling and line crossing in the Open field test and a reduction in frequency of transition, rearing and line crossing in the light/dark box. There was no significant difference in the chamber durations in the light/dark box test. Conclusion: Cataflam, Aspirin and the ethanolic extract of Cannabis sativa all have anxiogenic effect and reduced locomotor behaviour. The ethanolic extract of Cannabis sativa seems to have the greatest anxiogenic effect, followed closely by Cataflam and Aspirin.
Authors and Affiliations
C. O. Nku, G. O. Oghale, I. O. Ajiwhen
Keywords
Related Articles
- EP ID EP347095
- DOI 10.9734/BJMMR/2015/15032
- Views 62
- Downloads 0
Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients
Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are...
Nonalcoholic Fatty Liver Disease (NAFLD) in Saudi Patients with T2DM in Jazan Region: Prevalence and Associated Factors
Backgrounds: Non-alcoholic fatty liver disease (NAFLD) has become one of the major health problems world widely, especially among communities with sedentary lifestyle. The main objectives of this study were to know the p...
Estradiol and/or Ibandronate Therapy Ameliorates A Case Series Describing the Outcomes of Treatment in Co-infected Patients with HIV and Hepatitis C on the United States-Mexico Border
According to the National Health and Nutrition Examination Survey 2007-2010 (NHANES) and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the prevalence of Hepatitis C in people of Hispanic descent is 1.5...
Unsedated Colonoscopy: Experience from an Endoscopy Centre
Aim and Objective: Colonoscopy is generally considered a painful procedure requiring sedation. Due to the high cost of sedation colonoscopy, coupled with the attendant morbidity and mortality, there is a general trend to...
ABO and Rh Blood Group System and Periodontal Disease - A Prevalence Study
Background: Varied literature is documented exploring the relationship between ABO blood group and prevalence of oral and dental diseases. The aim of this study was to investigate the correlation of periodontal disease w...