Lung malignancies in HIV infected patients
Journal Title: The Journal of Medical Research - Year 2017, Vol 3, Issue 2
Abstract
Respiratory diseases including malignancies are a significant source of morbidity and mortality among patients infected with HIV. Malignancies such as Kaposi Sarcoma (KS) and Non Hodgkin Lymphoma (NHL) have for long been associated with HIV infection and reduced immunity. In addition to the AIDS-defining malignancies, patients infected with HIV are also at increased risk for developing several non-AIDS-defining malignancies including lung cancer. Electronic literature search for relevant studies was carried out online. Two hundred and seventy five publications were identified by the search. One hundred and thirty two relevant articles were summarized after scrutinizing their abstracts. There is an increased incidence of certain AIDS defining lung malignancies with viral etiologies such as NHL and KS. Likewise other non-AIDS defining malignancies without any clear viral etiology such as lung cancer have demonstrated a rise in prevalence especially in the era of HAART. Immune system dysfunction in HIV infection as well as some peculiar lifestyles has been implicated for this excess risk. HIV patients with pulmonary malignancies generally present late with advanced disease due to delays in making a diagnosis. Diagnosis of lung malignancy in HIV usually involves more extensive diagnostic investigations and invasive procedures. Treatment of lung malignancies in HIV patients is generally similar to the non-HIV patient but with some considerations such as drug-drug interaction, drug toxicity and immune reconstitution inflammatory syndrome. This review will examine the epidemiology, risk factors, diagnosis and clinical management of pulmonary malignancies in patients infected with HIV.
Authors and Affiliations
Umoh VA, Ekpe EE
Keywords
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- EP ID EP442585
- DOI 10.31254/jmr.2017.32013
- Views 126
- Downloads 0
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