Lycopene and Intralesional Steroid Injections in the Management of Oral Submucous Fibrosis- A Comparative Study.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Aim: To determine the efficacy of lycopene in the treatment of oral submucous fibrosis (OSF) and to compare it with intralesional triamcinolone acetonide injections. Materials and Methods: 40 Grade II and Grade III OSF subjects who were diagnosed clinically were included in the study. These patients were divided into two groups A & B; each containing 20 subjects. Group A patients were given oral lycopene 16mg per day, 8mg in morning and 8mg at night. Group B received intralesional injections of 10mg/ml triamcinolone acetonoide mixed with lignocaine for 8 weeks biweekly. Evaluation of treatment effect was done on day 15, 30, 45 and 60 for improvement in mouth opening and reduction in burning sensation. Results: All 40 patients were males. Mean improvement in mouth opening in Group A subjects was 1.30mm and in Group B was 1.8mm. Reduction in burning sensation in Group A was 3.10 and 3.8 in Group B on VAS. The p value (<0.001) was statistically significant. Conclusion: Lycopene in OSF patients results in substantial reduction in burning sensation with marginal improvement in mouth opening.
Authors and Affiliations
Dr Anusuya G. Savalagi
Keywords
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