Magic Mouth Wash V/s Benzydamine Mouth Wash in Prophylaxis and Treatment of Radiation Induced Oral Mucositis in Patients with Head and Neck Cancers: A Prospective Study
Journal Title: Indian Journal of Cancer Education and Research - Year 2018, Vol 6, Issue 1
Abstract
Background: The incidence of mucositis is increased by adding concurrent chemotherapy as well as by altered fractionation radiation. The main aim of the study is to compare the efficiency of magic mouth wash and benzydamine mouth wash in prophylaxis and treatment of radiation induced oral mucositis in patients with head and neck cancers. Materials and Methods: The present randomized, comparative study conducted at Department of Radiotherapy at Guru GobindSingh Medical College and hospital a period between April 2016June 2016. A total of 60 patients with head and neck cancer being treated with 6 or more weeks of radiotherapy to a total dose of 66Gy, 200cGy per day, 5 days a week,with shrinking field technique using 2D conventional method on cobalt teletherapy machine were randomly assigned to receive either the magic mouthwash (group A) or benzydamine (Group B) with equal number of patients i.e 30 patients in each group. All the results obtained were arranged in a tabulated form and analysed using SPSS software. Results: In the present study, the distribution of patients according to age was comparable in both groups. The mean age was 57.033 ± 12.397 in group A and 54.633 ± 11.418. There was no development of severe mucositis (grade 34) until week 3rd of treatment in both the groups. 4 patients (13.3%) in group B developed grade 34 mucositis in 4rth week. In the 5th week 1 patient (3.33%) in group A and 6 patients (20%) in group B developed grade 34 mucositis. In the 6th and the 7th week 3 patients (10%) in arm A and 6 patients (20%) in arm B developed severe reactions in each of these weeks respectively. Conclusion: From the above study, we can conclude that mouthwashes are an effective alternative for managing cases of mucositis, with magic mouth wash giving better results but there was no significant difference between both the groups.
Authors and Affiliations
Yashna Gupta
Keywords
Related Articles
- EP ID EP569084
- DOI 10.21088/ijcer.2321.9815.6118.6
- Views 118
- Downloads 0
Can Accurate Pre Operative Assessment of Axillary Lymph Node in Breast Cancer Avoid Axillary Dissection?
Background: The Axillary Lymph node status is of paramount importance in staging, treatment planning, prognosis and survival in Breast Cancer. Hence appropriate investigating criteria for AXLN assessment, which is easy,...
Clinical Profile and Therapy of Hepatocelluar Carcinoma at a Tertiary Care Institute from South India: A Retrospective Study of 182 Patients
Objective: To study the clinical profile and therapy of hepatocellular carcinoma (HCC) at a tertiary care institute in Andhrapradesh, Southindia. Methods: Data analysis of HCC patients enrolled in between 2000 and 2015....
Male Breast Cancer with Skeletal Metastasis: A Case Report and Review of Literature
While it is the most common malignancy in women, breast cancer is rare in men and thus often ignored or overlooked, which leads to delayed diagnosis for the already fulminant condition. Bone is the most common location f...
Comparison of Different Phenotypic Tests for Detection of ESBL (Extended Spectrum Beta Lactamases) Producing Pseudomonas Aeruginosa
Background: P. aeruginosa is the most common nosocomial pathogen encountered and a known organism causing high mortality and morbidity. Due to indiscriminate antibiotic use, resistance is very commonly known in them and...
Microbiological Analysis of Hospital Acquired Infections in Burn Patients
Introduction: About 75% of the mortality associated with burn injuries is related to sepsis, especially in developing countries. Since it is desirable to carry out periodic reviews of bacterial flora of burn wounds and e...