MAGNESIUM SUPPLEMENTATION IN CARDIOVASCULAR DISEASES : A SYSTEMATIC REVIEW
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2018, Vol 27, Issue 27
Abstract
OBJECTIVES: The aim of this study was to clarify the role of Mg2+ in diseases linked to cardiovascular risks. METHODS: A retrospective systematic review of the Medical Literature Analysis and Retrieval System Online and Latin American (MEDLINE) and Caribbean Literature in Health Sciences (LILACS) databases was performed. The following keywords were used for queries: “magnesium supplementation,” “diabetic,” and “lipid profile.” The inclusion criteria for the selection of papers were as follows : original articles or systematic reviews with and without meta-analyses, published between January 2007 and April 2017. Studies that were unrelated to magnesium replacement and cardiovascular function as well as case reports were excluded. RESULTS: Initially, 472 articles were obtained. After applying the inclusion and exclusion criteria, 13 articles were evaluated. Overall, Mg2+ supplementation had a favorable effect on glycemic and lipid indexes in patients with diabetes and/or pre-diabetes. Two studies demonstrated that Mg2+ did not have a significant effect on laboratory test results. In these studies, 62.5% of patients had uncontrolled hbA1c and dyslipidemia, 41% were obese, and 82% had HOMA-IR ≥ 2.5. CONCLUSION: Mg2+ supplementation may contribute to reductions in the risks of cardiovascular diseases. However, owing to the conflicting results, additional complementary studies are needed, not only to improve our understanding of the beneficial pathways involving Mg2+, but also to facilitate the development of robust guidelines for clinical practice.
Authors and Affiliations
Ricardo Silva Tavares, Barbara Rocha Gonçalves 2 , Breno Oliveira de Assis 3 , Emílio Ernesto Garbim Júnior 4 , Jullyana Egito Peixoto Costa
Keywords
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