Measurement Issues in the Use of Cognitive Neuroscience Tasks in Drug Development for Impaired Cognition in Schizophrenia: A Report of the Second Consensus Building Conference of the CNTRICS Initiative

Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4

Abstract

This overview describes the goals and objectives of the second conference conducted as part of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. This second conference was informed by a series of online surveys and brought together basic and clinical scientists from academia and industry to address the concerns central to each field of research. Our goal was to develop recommendations for future research addressing the psychometric and practical challenges involved in translating paradigms from cognitive neuroscience into tasks that are feasible for use in the treatment discovery and development process. In this overview article, we describe the series of talks that were presentations at the conference. This article serves as an introduction to the set of articles included in this special issue that provide overviews and discussions of the issues raised and the recommendations made in these talks and in the subsequent discussions at the meeting. In addition, we describe the online surveys conducted in the month before the conference that were used to obtain suggestions from the field as to important task selection criteria and to generate initial benchmark goals for psychometric development for cognitive neuroscience tasks.

Authors and Affiliations

Deanna M. Barch, Cameron S. Carter, the CNTRICS Executive Committee

Keywords

Related Articles

Theory of Mind and Schizophrenia: A Positron Emission Tomography Study of Medication-Free Patients

Background: “Theory of mind” (TOM) refers to the ability to attribute mental states (ie, beliefs and goals) to one's self and others and to recognize that behaviors are guided by these mental states. This...

Implications of Clinical Trial Design on Sample Size Requirements

The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison group...

Manganese-Enhanced MRI: An Exceptional Tool in Translational Neuroimaging

The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing...

Using Event Related Potentials to Explore Stages of Facial Affect Recognition Deficits in Schizophrenia

Schizophrenia patients show impairments in identifying facial affect; however, it is not known at what stage facial affect processing is impaired. We evaluated 3 event-related potentials (ERPs) to explore stages of facia...

Abnormal Superior Temporal Connectivity During Fear Perception in Schizophrenia

Patients with schizophrenia have difficulty in decoding facial affect. A study using event–related functional neuroimaging indicated that errors in fear detection in schizophrenia are associated with paradoxicall...

Download PDF file
  • EP ID EP683273
  • DOI  10.1093/schbul/sbn037
  • Views 85
  • Downloads 0

How To Cite

Deanna M. Barch, Cameron S. Carter, the CNTRICS Executive Committee (). Measurement Issues in the Use of Cognitive Neuroscience Tasks in Drug Development for Impaired Cognition in Schizophrenia: A Report of the Second Consensus Building Conference of the CNTRICS Initiative. Schizophrenia Bulletin, 34(4), -. https://europub.co.uk./articles/-A-683273