METFORMIN IN THE PREVENTION OF METABOLIC SYNDROME ASSOCIATED WITH INITIATION OF ATYPICAL ANTIPSYCHOTIC THERAPY IN ADOLESCENTS AND YOUNG ADULTS - A RANDOMIZED, OPEN LABELLED, SINGLE CENTERED STUDY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Objective: The aim of the study was to evaluate the effectiveness and safety of Metformin along with Risperidone to prevent antipsychotic-induced metabolic syndrome in first-episode schizophrenia patients.Methods: This was a randomized, open labelled, prospective study conducted in the Department of psychiatry, Tirunelveli medical college. Around 96 patients diagnosed with first episode schizophrenia were randomized into 2 groups. Group 1 patients were given T. Risperidone (2 mg twice daily, n=48) and group 2 patients were given T. Metformin (500 mg twice daily, n=48) along with T. Risperidone for 6 mo.The primary endpoint assessed was the proportion of patients developing metabolic syndrome at the end of 6 mo in both the groups. The secondary endpoints were the changes in body mass index (BMI), waist circumference (WC), fasting blood sugar (FBS) and triglycerides (TGL) from baseline to the end point.Results: There was a significant reduction in BMI and WC at the end of 3 mo (p<0.001) and at the end of 6 mo (p<0.001) when compared to baseline in group II individuals. There was a significant reduction in FBS and TGL levels at the end of 6 mo of treatment (p<0.001) in group II individuals. There was the significant statistical difference between both the groups (p<0.05) in terms of BMI, WC, FBS, triglycerides. The treatment emergent adverse effects with Metformin were generally mild and did not lead to any discontinuation.Conclusion: The use of Metformin along with Risperidone may have a better impact on the long-term cardiovascular morbidity and mortality of the schizophrenia patients. Keywords: Schizophrenia, Metabolic syndrome, Atypical antipsychotics, Body mass index, Waist circumference, Fasting blood sugar, Triglycerides
Authors and Affiliations
R. Vishnupriya, J. Ezhilramya, B. Meenakshi
Keywords
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