MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2013, Vol 0, Issue
Abstract
In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery. The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH = 5.5 at the temperature of 35 °C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data.
Authors and Affiliations
Maria Mucha, Iwona Michalak, Zbigniew Draczyński
Keywords
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