N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth

Journal Title: Journal of Cancer Sciences - Year 2015, Vol 2, Issue 2

Abstract

In this report, we present a novel histone deacetylase inhibitor (HDACi) (N-Hydroxy-6-(5-nitro-naphtalimide)-hexanamide: ES8) that efficiently inhibits angiogenesis in relevant ex vivo models (Human umbilical vein endothelial cells (HUVEC), 3D aortic ring assay) and in vivo (chick chorioallantoic membrane (CAM), Zebrafish). Transcriptomic profiling reveals a set of ES8 specific genes that are not affected by the prototypical HDACi suberoylanilide hydroxamic acid (SAHA). Finally, ES8 also reduced tumor growth in mouse models of small cell lung cancer. Availability of a novel compound not centered exclusively on inhibition of angiogenic factors and inducing a characteristic transcription profile may be of interest to overcome resistance to currently used chemotherapies.

Authors and Affiliations

S. David Nathanson

Keywords

Related Articles

Rectifying the Epigenetic Field Defect in Gastric Carcinogenesis

Gastric cancer is undoubtedly a fatal malignancy worldwide with high incidence and dismal prognosis. Its formation and development can be driven by genetic defects, dietary factors, alcohol consumption, viral infection,...

N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth

In this report, we present a novel histone deacetylase inhibitor (HDACi) (N-Hydroxy-6-(5-nitro-naphtalimide)-hexanamide: ES8) that efficiently inhibits angiogenesis in relevant ex vivo models (Human umbilical vein endoth...

Science has a Solution for Sonic Weapons Caused Cancer

U.S. personnel at the Embassy in Havana who’ve experienced arash of symptoms from mysterious sonic health attacks appear to have suffered widespread brain network dysfunction, but there’s no answer about the cause. A new...

Targeted Therapy in Advanced Gastric Cancer: An Updated Review

Despite great efforts over the years, adenocarcinoma of the stomach remains a difficult disease to manage. It is the second leading cause of cancer death and is the fifth most common cancer worldwide. If diagnosed early,...

Now is the Time for Personalized Imaging Protocols in Cancer Diagnosis and Radiotherapy

Since the discovery of X-ray in 1895, medical imaging procedures, particularly those involving ionizing radiation such as computed tomography (CT) and cone-beam computed tomography (CBCT), have been playing a crucial rol...

Download PDF file
  • EP ID EP209338
  • DOI 10.13188/2377-9292.1000008
  • Views 115
  • Downloads 0

How To Cite

S. David Nathanson (2015). N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth. Journal of Cancer Sciences, 2(2), 1-11. https://europub.co.uk./articles/-A-209338