MICRONUCLEUS ASSAY IN UROTHELIAL CELLS IS A DIAGNOSTIC INDICATOR IN CARCINOMA CERVIX
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 30
Abstract
[b]AIM[/b]: Identification of micronuclei in exfoliated urothelial cells and comparison of this with Micronucleated cells from cervical smear. [b]MATERIALS AND METHODS[/b]: This study included 50 histopathologically confirmed cervical carcinoma patients and age matched 50 controls. Cervical smear and urine samples were collected from each patients then processed and stained. Slides were observed under microscope to detect micronucleus. About 200-500 cells were observed from each sample. [b]RESULTS:[/b] The obtained data showed frequency of micronuclei present in urothelial cells were more than that of the cervicalsmear. The increase in number of micronucleus was observed as the stage of carcinoma advances. This indirectly helps in identification of severity of the carcinoma. [b]CONCLUSION[/b]: Our study reveals that the identification of Micronucleated cells in urothelial cells can be used as a screening test in mass screening programs as it is an easy and reliable technique which can detect chromosomal instabilities rapidly.
Authors and Affiliations
Jayasabarinathan M, Sohinder Kaur, Vijayadevi S
Keywords
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- EP ID EP133028
- DOI 10.14260/jemds/2015/751
- Views 89
- Downloads 0
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