ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF LEAF EXTRACT OF MORINDA CITRIFOLIA IN EXPERIMENTAL MODELS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2011, Vol 1, Issue 1
Abstract
Morinda citrifolia is a medium sized evergreen tree belongs to Rubiaceae family. The petroleum ether extract ofMorinda citrifolia (PMC) leaves was investigated for the evaluation of anti- inflammatory and analgesic activity. Acute toxicitystudies were performed as per OECD-423 guidelines. Toxicity signs and symptoms were not observed. Anti-inflammatoryactivity was established by carrageenan induced paw edema and cotton pellet induced granuloma at the dose of 200 and 400mg/kg. Analgesic activity was carried out by tail immersion method in mice. The activity may be due to the presence of steroidsin the extract. The extract exhibited significant analgesic and anti- inflammatory activity, which supports the traditional utilizationof the plant. This study established analgesic and anti- inflammatory activity of the leaf of Morinda citrifolia.
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