DESIGN AND EVALUATION OF GELATIN MICROSPHERES CONTAINING DICLOFENAC SODIUM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2011, Vol 1, Issue 1
Abstract
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which arebiodegradable in nature and ideally having a particle size less than 200 μm. The present study is aimed to formulate theDiclofenac Sodium (DFS) microspheres by using Co-acervation phase separation procedure to get better bioavailability of drug.In this study, we used DFS as a drug of choice since it has biological half-life of about 1-2 hrs. DFS microspheres wereformulated by using different drug, gelatin and HPMC ratios. A total of 6 batches was F1, F2, F3, F4, F5 & F6 of varyingconcentrations of drug, gelatin and HPMC were prepared. DFS microspheres were evaluated by various tests like particle sizeanalysis, angle of repose and bulk density. Further DFS Micro spheres were examined for in-vitro dissolution, by usingphosphate buffer (PH 7.4) to make out the release of the drug. Results shown that microspheres with low amount of gelatin(F1), with high amount of HPMC (F4 & F5) has shown satisfactory prolonged action in invitro dissolution studies.
Authors and Affiliations
Umamahesh B , Lavanya N , Kusuma P Kumar , SR Guggilla
Keywords
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