Central arterial stiffness in Zambian normotensive and hypertensive participants
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 1
Abstract
Central arterial stiffness is a strong and independent predictor of cardiovascular events and mortality including hypertension in any given population. A few studies have found that being black could be associated with elevated arterial stiffness thereby accounting for the high prevalence of hypertension in them. The present study sought to determine and compare central arterial stiffness using Carotid femoral PWV (cfPWV) in a population of Zambian normotensive (NT) participants and hypertensive (HT) participants (both treated hypertensives (HTC) and untreated hypertensives (HTN)) between 30 – 65 years of age. CF PWV was measured in 146 participants. A Complior® Analyse device (Version 1.9 Beta 2013; ALAM-Medical, France) was used. Superficial pulses were accessed noninvasively over the carotid– femoral segment. The cfPWV values in HTN participants (N=23) were significantly higher than in NT (N=64) participants (11.4±4.2 vs 9.1±3.2, p=0.009). In HTC participants (N=59), their cfPWV values (10.4±5.6) tended to approach those in HTN participants, with no statistical differences between them (p > 0.500). Furthermore, the mean cfPWV found in NT participants was considerably higher than any found in previous studies. Carotid femoral PWV did not show significant age – related increase in all three blood pressure categories (r2 < 0.03, p > 0.100). These findings show that central elastic arteries of HT participants are stiffer and thus less compliant than those in NT participants adding to their burden of hypertension. Regrettably, HTC participants showed poor BP control inferring from their considerably high cfPWV values.
Authors and Affiliations
Festus Mushabati, Fastone Goma, Lukubi Lwiindi, Nathan Siulapwa, Seter Siziya
Keywords
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