Signet ring cell adenocarcinoma of the urinary bladder: A review of the literature.
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 2
Abstract
Signet-ring cell carcinoma of the urinary bladder is a rare tumour which most clinicians have not encountered in their practice. We have reviewed the literature on signet-ring cell carcinoma of the urinary bladder in order to document its presentation, diagnosis, differential diagnosis, management and management outcome. Various internet search engines were used to identify case reports, case series and review papers on signet-ring cell carcinoma which formed the pivot for the literature review. Signet-ring cell adeno carcinoma of the urinary bladder is a relatively rare variant of adenocarcinoma of the urinary bladder. It has signet-ring type cells with intracytoplasmic mucin. This diagnosis is limited to 25% or more signet-ring type cells in the bladder tumour. Signet-ring cell adenocarcinomas of the urinary bladder occur more commonly in females and they tend to present with haematuria. Signet-ring cell adenocarcinoma exhibits diffuse infiltration of the bladder similar to that of linitis plastica of the stomach and it is associated with poor prognosis. Histological examination of the bladder characteristically shows signet-ring type cells which on immunohistochemical staining stain positively with cytoleratin and usually with mucin. Signet-ring cell adenocarcinoma of the urinary bladder may be primary or it may be secondary from stomach, breast or from other organs or direct extension from the prostate or rectal adenocarcinoma. Cystectomy is the treatment of choice that would improve the prognosis of primary signet-ring cell adenocarcinoma of the urinary bladder. Signet-ring cell adenocarcinoma of the urinary bladder is a relatively rare tumour which could be: (a) a primary tumour; (b) result of direct extension from adenocarcinoma of prostate or rectum; (c) a metastatic tumour with the primary tumour originating from elsewhere including the stomach and breast. When a signet-ring cell carcinoma of the bladder is found on histological examination the patient should be carefully investigated to exclude metastatic tumour or direct extension from nearby organs. In cases of primary signet-ring cell carcinoma of the urinary bladder so far cystectomy is the treatment that would improve survival.
Authors and Affiliations
Anthony Kodzo Venyo, Khalid Ahmed
Keywords
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