Comparison of preemptive ketamine on postoperative analgesic effect between major open and major laparoscopic gynecological surgery
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 1
Abstract
Objective of the study was to compare the preoperative ketamine on postoperative pain relief action between major open and major laparoscopic surgical procedures in female Jordanian population. Our investigation included 119 female adult patients, aged 31-55 years, classed I-II by the American society of Anesthesiologists (ASA) and scheduled for different elective major open and major laparoscopic surgical interventions under balanced general endotracheal anesthesia after obtaining written informed consent from all participants at King Hussein hospital, King Hussein medical city, Amman, Jordan, during the period Jan 2012-Jan 2014. All the participants were divided according to type of surgical approach into two groups. Group I patients (n=59) were exposed to major open gynecological surgery and group II patients (60) were exposed to major laparoscopic gynecological surgery. In both groups, intramuscular ketamine 0.5 mg/kg was administered after general intravenous anesthesia was induced and 5 minutes before incision was made. Postoperative pain relief quality was evaluated using the numerical pain rating scale (0-10) where 0=no pain, 1-3=mild pain, 4-6=moderate pain, 7-9=severe pain and 10=worst severe pain; time to first pain killer demand and total analgesic consumption, during the first 24 postoperative hours. Results were statistically assessed using the student‘t’ test with a probability value less than 0.05 considered significant. The mean score was 7.2, 5.9 and 5.2 at 0.2 and 6h time intervals, respectively in group I. The mean score was 5.1, 4.2 and 3.4 at 0.2 and 6h time intervals, respectively in group II (P<0.05). Intramuscular ketamine 0.5mg/kg administration after induction of intravenous general anesthesia and 5 minutes pre-incision shows a preemptive action in decreasing pain after gynecological laparoscopic surgery.
Authors and Affiliations
Basel Khreisat, Mitri Rashed, Wesam Khraisat
Keywords
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- EP ID EP106260
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