Effect of Ethanolic Extract of Garcinia Kola Seed on Some Reproductive Parameters of Male Wister Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 3
Abstract
The ethanolic extract of Garcinia kola seed was investigated for its activity on selected haematological parameters of male wistar rats. Thirty (30) male wistar rats weighing 150.42 ± 3.98 were divided into three groups (I, II and III) comprising ten animals each. Animals in group I (control) received 0.5 ml of distilled water while those in groups II and III were administered 100 and 200 mg/kg body weight of the extract respectively once daily. After 3 weeks of extract administration, 5 rats from each group were sacrificed. Same was done after 6 weeks. Preliminary phytochemical screening of ethanolic extract of Garcinia kola seed revealed the presence of alkaloids, saponins, tannins, carbohydrate, steroids and flavonoids. The lethal dose (LD50) of the extract was found to be safe up to 5000 mg/kg body weight. Results of this study revealed that the extract has no significant (p > 0.05) change on body weight. However the weight of testes decreased significantly (p < 0.05) in groups II and III after 3 weeks of administration. The change in weight was not significant (p > 0.05) at 6 weeks of administration. The weight of the epdididymis increased significantly (p < 0.05) in group III after 6 weeks of administration. Serum testosterone levels increased significantly (p < 0.05) ingroup III after 3 weeks and groups II and III after 6 weeks of administration. The administration of the extract caused a significant (p < 0.05) increase in sperm count in groups II and III at 3 weeks and group III at 6 weeks. Sperm motility increased significantly (p < 0.05) whereas percentage of abnormal sperms decreased significantly (p < 0.05) in groups II and III at 3 and 6 weeks of treatment. This study has shown that administration of 100mg/kg and 200mg/kg of G kola ethanolic extract for 6 weeks enhances sperm characteristics in wistar rats
Authors and Affiliations
Denen Atsukwei1 , Samuel O. Odeh2 , Egesie U. G. 2 , Joseph E. Toryila3
Keywords
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