EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF VARIOUS EXTRACTS FROM WHOLE PLANT OF Bridelia scandens IN CCL4 INDUCED HEPATOTOXICITY RATS
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 3
Abstract
ABSTRACT Objective: To evaluate the hepatoprotective activity of various extracts from whole plant of Bridelia scandens in CCl4 induced hepatotoxicity rats. Methods: The shade dried whole plant powder was extracted with various solvents (pet. ether, ethyl acetate and methanol) by using Soxhlet extractor and crude various extracts used for acute toxicity and hepatoprotective activity. To estimate in serum the biochemical parameters like SGOT, SGPT, ALP, creatinine, urea, total bilirubin, total cholesterol, triglycerides, total protein and albumin. Results: The zero percent mortality for various extracts of whole plant of Bridelia scandens were found at the doses of 2000mg/kg. The methanolic extract of whole plant of B. scandens treated rats were significant reduction the level of SGOT, SGPT, ALP, creatinine, urea, total bilirubin, total cholesterol & triglycerides when compared to other extracts. And also significantly elevated the level of total protein and albumin when compared to other two extracts. The level of total bilirubin, urea and creatinine had a dose dependent reversal of the effects on this parameter. Conclusion: From the present experimental study it can be concluded that methanolic extract of Bridelia scandens exhibited significant hepatoprotective activity against CCl4 induced hepatotoxicity in rats, as result showed in biochemical parameters. Key words: Hepatotoxicity, Bridelia scandens, CCL4, Various extracts.
Authors and Affiliations
D. Senthil Kumar, A. Kottai Muthu* and J. Amutha Iswarya Devi
Keywords
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