MICROSPONGES: A NOVEL DRUG DELIVERY SYSTEM FOR CONTROLLED DELIVERY OF TOPICAL DRUGS
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 2
Abstract
ABSTRACT Even though possess several advantages topical formulations have some drawbacks such as the need to contain high concentrations of active agents for effective therapy due to the low efficiency of delivery system, resulting into irritation and allergic reactions in significant users. Other drawbacks of topical formulations are uncontrolled evaporation of active ingredient, unpleasant odor and potential in-compatibility of drugs with the vehicles. These drawbacks are overcome by microsponge drug delivery system. Microsponge delivery system consists of a polymeric bead having network of pores held with an active ingredient which maximizes the retention time of an active ingredient either on skin surface or within the epidermis thereby providing controlled release of drugs. Microsponge possess the versatility to load a wide range of actives providing the benefits of enhanced product efficacy, mildness, tolerability, and extended over to a wide range of skin therapies. Microsponge delivery system can be incorporated into conventional dosage forms such as creams, lotions, gels, ointments, and powder and share a broad package of benefits. This review covers the advantages of microsponges, their formulation and applications in pharmaceutical field. Keywords: Topical, Microsponge, polymers, Vehicle, Epidermis.
Authors and Affiliations
Yerram Chandramouli*, Shaik Firoz, B. Rubia Yasmeen, Amaravathi Vikram, B. Mahitha, U. Aruna
Keywords
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