Physiological response of uterine muscle to Steganoteania araliacea in rat models
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 1
Abstract
The bark root of Steganotaenia araliacea Hochst (Umbelliferae) nicknamed “herbal pitocin” is used by traditional circle in Zambia to induce labour in pregnant women. This work was aimed at investigating the contractile stimulatory effects of the aqueous extracts of Steganotaenia araliacea (SAEª) on isolated smooth muscle preparations of the rat uterus to explain its reported local use. Objective of the study was to determine the physiological effect of SAEª root extract (nicknamed “herbal Pitocin’’) on pregnant and non-pregnant uterine muscle. This work examined the effect of the aqueous extract of SAEª extract on rat uterus pre-treated with 1 mg/kg stilboesterol for 24 h and also on the pregnant rat uterus. The effects of reference agonists like oxytocin (OT) and Acetylcholine (Ach) were used and also antagonists like atropine (AT), indomethacin (Indo) and Salbutamol (SBM) on the uterine contractile effect of the extract were investigated. In vitro studies of SAEª on uterine tissue showed contractile activity which was dose dependant similar to OT and Ach while pre-treating the tissue with atropine, indomethacin or Salbutamol before administering the extract showed the inhibitory effects of the drug Salbutamol on the activity of the extract. The inhibition of contractile effect of the crude aqueous extract of Steganotaenia araliacea shown by Salbutamol (p < 0.05) suggests the probable stimulation of the Oxytocin-like receptors of the uterus by the extract. These physiological finding justify the traditional use of the plant for its uterotonic properties.
Authors and Affiliations
Lukubi Lwiindi, Faston Goma, Festus Mushabati, Lavina Prashar, Kennedy Choongo
Keywords
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