NEPHROPROTECTIVE ACTIVITY OF CYANOTIS FASCICULATA VAR., FASCICULATA AGAINST CISPLATIN INDUCED NEPHROTOXICITY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
Cisplatin is quite effective against various neoplastic diseases, but its potential nephrotoxicity leads to increased morbidity, complications and hospitalization costs. Prevention of nephrotoxicity may allow clinicians to administer higher doses for added therapeutic benefits. So, the present investigation was designed to evaluate the ability of the 70% hydro-alcoholic extract of Cyanotis fasciculata Var., fasciculata (CFEE) to combat Cisplatin induced nephrotoxicity. Where, CFEE demonstrated dose dependent decrement of elevated biochemical markers of nephrotoxicity along with significant restoration of protective-GSH levels and suppression of LPO levels in tissues. Further, the remarkable renal-cellular rejuvenation found in histopathological studies also enunciated the organ protective activity of CFEE. It was concluded that, in addition to polyphenolics, some of the phyto-fragments found during GC-MS analysis might also contributed to the protection offered by CFEE.
Authors and Affiliations
R. L. N Murthy , H. N Nataraj , Ramachandra Setty
Keywords
Related Articles
- EP ID EP155874
- DOI -
- Views 115
- Downloads 0
SYNTHESIS OF NEW 1, 3, 7, 8-TETRASUBSTITUTED XANTHENES ANALOGUE
Theophylline, a methyl xanthenes compound, is known as an efficient bronchodilator drug, having also anti-inflammatory and immunomodulatory effects. In order to improve its pharmacological profile and to reduce also the...
IMPLICATIONS FOR SUPPLEMENTATION OF DIETARY ENZYMES IN POULTRY FEED: A REVIEW
The present review highlights the effect of dietary enzyme supplementation on different body growth parameters of poultry birds at their various growing stages. The article stresses on the effect of dietary enzymes on va...
STUDY ON ENDOCRINOLOGICAL PROFILE OF HIV INFECTED MALE PATIENTS FROM EASTERN INDIA
Human Immunodeficiency virus (HIV) infectionis associated with a variety of endocrine problems. Hypoadrenalism, hypothyroidism and hypogonadism are commonly found singly or in combination. Especially, male hypogonadism i...
ANTICANCER AND CYTOTOXIC POTENTIAL OF TRITICUM AESTIVUM EXTRACT ON HELA CELL LINE
The objective of the study was to analyze the anticancer property of the leaves of Triticum aestivum on HeLa cells. The Indian medicinal plant Triticum aestivum that is used in traditional medicine for cancer and non can...
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT OF POLYGALA JAVANA DC. WHOLE PLANT
The study was intended to evaluate the anti-inflammatory activity of the whole plant of Polygala javana. The anti-inflammatory activity study was carried out by using Carrageenan induced paw edema. The ethanol extract o...