Neurocognitive Developmental Outcomes in Early Adolescent Rats Prenatally Exposed to Choline and Docosahexaenoic Acid
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
ABSTRACT Introduction: Prenatal nutritional status plays a remarkable role in neurocognitive development of an offspring. Although, essential nutrients like iron, calcium, and vitamins are being supplemented during pregnancy, very few studies have focussed on essential brain nutrients and its role on foetal mental development and neurocognitive outcomes through ageing. Studies show that prenatal supplementation of essential brain nutrient such as choline alone enhances learning and memory functions and protects adult rats against spatial memory deficits across the lifespan. Similarly, studies also show that supplementation of Docosahexaenoic Acid (DHA) during pregnancy confers positive developmental outcomes in the offspring such as increased birth weight, enhanced visual acuity, hand to eye coordination, attention, problem solving and information processing. Aim: To assess the neurocognitive developmental outcomes of early adolescent rats prenatally supplemented with either choline or DHA or both. Materials and Methods: E0 Day pregnant dams were divided into five groups 1: Normal control, 2: Saline control 3: Choline 4: DHA, 5: Choline+DHA. Pregnant dams from the normal control group were undisturbed in their home cage and were provided normal animal feed and water ad libitum. Saline, choline (4.6 mmol/kg/day) and DHA (400 mg/day of DHA) were supplemented to appropriate groups during the same period. Subsequent to weaning period, rat pups from all groups of dams were subjected to t-maze and passive avoidance tests. Results: The behavioural studies indicate that offspring prenatally treated with (Group 5) both choline and DHA showed significantly (p<0.001) enhanced memory and learning ability, when compared to the same in age matched untreated groups or those treated with choline and DHA alone separately. Conclusion: Synergistic supplementation of choline and DHA rather than anyone of them singly during foetal development periods enhances their neurocognitive outcomes during early adolescence.
Authors and Affiliations
Rajarethnem Huban Thomas, Kumar MR Bhat, Siva Kumar Gopalkrishnan, Raghu Jetti, Rajesh Thangarajan, Manikam Indujaa, Kiranmai S Rai
Keywords
Related Articles
- EP ID EP515973
- DOI 10.7860/JCDR/2018/29563.11038
- Views 64
- Downloads 0
Delirious State and Agitation Following Heparin Induced Stevens-Johnson Syndrome
Letter to Editor
Risk Factors for Peripartum Wound Dehiscence
ABSTRACT Introduction: Wound Dehiscence (WD) following Vaginal Delivery (VD) or Cesarean Delivery (CD) causes considerable discomfort to the woman, leading to significant physical, emotional and financial burden. The rat...
Comparison of Refractive Error Measurements between KR-1W Wavefront Analyser and KR-8800 Automatic Refractometer in School Children
ABSTRACT Introduction: A number of methods and instruments, such as retinoscopy, Hartmann-Shack sensor, ray tracing method and rotary prism technology, are available for assessing refractive status in clinic. The literat...
Candida Funisitis: Common Organism with Uncommon Presentation
ABSTRACT Funisitis is the inflammation of umbilical cord while, chorioamnionitis is inflammation of placental membranes i.e., chorion and amnion. The mucus plug in lower genital tract acts as barrier during pregnancy. Th...
The Impact of Three-month Training Programme on Foot Care and Self-efficacy of Patients with Diabetic Foot Ulcers
Introduction: Patient’s self-efficacy in disease management and foot care is considered as an important indicator in controlling the complications of diabetes. Aim: This study was aimed to determine the effect of threemo...