NEUROPROTECTIVE POTENTIAL AND EFFICACY OF NEURODEGENERATIVE DISORDERS OF FRUIT EXTRACT OF AEGLE MARMELOS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: To evaluate the neuroprotective and neurodegenerative disorder of Aegle marmelos.Methods: The present study was carried out to evaluate the Alzhiemer and Parkinsonism disorders by Actophotometer test. Water maze test and Reserpine induced Parkinsonism models in sodium nitrite induced hypoxic rats.Results: The Aegle marmelos fruit extracts improved the cognitive defects in hypoxic rats. The inquiry into behavioral studies indicates that sodium nitrite induced neurotoxicity, decreases the locomotor activity and decreases the habituation memory. The study shows a significant reduction (p<0.01) in both doses (200mg/kg and 400mg/kg) of Aegle marmelos extract in water maze test and locomotor activity test. Also the experiment showed the significant reduction in muscular rigidity by decreasing the gripping latency on the rod. The Aegle marmelos fruit extract produced a reduction in the Acetylcholin esterases (AChE) and glutamate levels but significantly increased in dopamine level. Increasing in AChE activity indicates that it ameliorates cholinergic function by inhibiting sodium nitrite which induces increase in AChE activity.Conclusion: This study strongly suggests that the Aegle marmelos fruit extract attributed its prominent Alzheimer and Parkinsonism activity.Â
Authors and Affiliations
Kasireddy Paulbabu, Khumanthem Deepak Singh, Prashanti P, Manguluri Padmaja
Keywords
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