New Anti-aflatoxin marine and Terrestrial extracts with assessment of their Antioxidants, Antimicrobial, Glycemic and Cholinergic properties bioscreening of new Anti-aflatoxin natural extracts
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 3
Abstract
Aflatoxins are a group of closely related mycotoxins that are widely distributed in nature in different agricultural communities. These toxins can produce a variety of diseases related to liver and brain damage. In this study, the phytochemical constituents of different plants ethanolic extracts (Thymus vulgaris, Cinnamuom zeilanicum, Menthe Pulegium, Adiantum capillus and Berberis vulgaris) and algae extracts (Ulva lactuca, Jania ruben and Petrocladiella capillacea) were examined as antifungal, antibacterial, antioxidant beside cholinergic and glycemic behaviours. The extracts antifungal activity was examined both on the Aspergillus flavus growth and on aflatoxins production. Results showed that both tested C. zeilanicum concentrations gave undetectable Aflatoxins B1 and B2 levels, while B. vulgaris (1%) decreased B1 concentrations than control. Furthermore, it was found that B. vulgaris act as potent anti-AChE while the other tested terrestrial and marine extracts acted as activators. Additionally, B. vulgaris and marine algae extracts showed inhibitory effects toward α-glucosidase activity. As the growth of A.flavus affected by our tested extracts, differential display was performed on fungus genome to study up-down regulation. Results showed alteration in A. flavus gene expression at different concentrations of C. Zeilanicum and B. vulgaris (0.1%, 0.5% and 1%) that confirmed the alterations that took place in aflatoxins production. In conclusion, this study showed the positive effect of our extracts as anti- aflatoxin so they could be used as preservative during food storage and as aflatoxicosis therapeutic extracts.
Authors and Affiliations
Nadia Fouad
Keywords
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