NEW FRONTIERS OF TARGET THERAPY IN ONCOLOGY: ACUTE PROMYELOCYTIC LEUKEMIA
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 1
Abstract
By introduction of all-trans retinoic acid (ATRA) in de novo acute promyelocytic leukemia (APL) an revolution in therapy of this disease has been made. The rate of molecular complete remissions (CR) have been doubled compared to conventional chemotherapy with anthracyclines ranging from 90% to 95%. Consolidation therapy is required in order to reduce the risk of early relapse. Maintenance therapy is recommended as it further reduces the risk of relapse, especially in high-risk patients. The relapse rate in APL is relatively high, about 30% and is the most common within three years of starting the treatment. Another agent, arsenic trioxide (ATO) is the optimal drug that achieves high CR rate in relapsed, approximately 80% and hematopoietic stem cell transplantation (HSCT) may prolong the overall survival in patients with APL. ATRA and ATO have become a paradigm of targeted therapy, and APL is a paradigm of curable disease, at least in comparison to other forms of acute myeloid leukemia (AML).
Authors and Affiliations
Ivan Petković, Ivica Pejčić, Svetislav Vrbić
Keywords
Related Articles
- EP ID EP157470
- DOI 10.2478/afmnai-2014-0002
- Views 129
- Downloads 0
Giant Basal Cell Carcinoma: A Case Report - - - Džinovski bazocelularni karcinom kože: prikaz slučaja
Basal cell carcinoma (BCC) is the most common type of skin cancer and the most common type of tumor in the human population in general. Clinical variants of BCC include nodular, superficial, pigmented, morpheaform, cysti...
KARAKTERISTIKE BOLESNIKA LEČENIH PSIHOTERAPIJOM U AMBULANTNIM USLOVIMA
Socijalne promene u tranzicionoj zemlji i u tranzicionom vremenu dovele su do promena u strukturi bolesnika koji traže psihoterapijsku pomoć. Ipak, do sada nije bilo istraživanja karakteristika bolesnika na psihoterapijs...
Basic Principles of Simulations: In situ and Online Simulation - - - Osnovni pricipi simulacije: In Situ i Online simulacija
Medical simulation is an artificial and a faithful representation of real clinical situations with the help of static and interactive doll simulators, standardized patients/actors, models for the exercise, simulation on...
PORTNA HIPERTENZIJA - PREVENCIJA REKRVARENJA
Cilj studije bio je da se predstavi značaj medikamentne terapije u ranoj prevenciji krvarenja i ponovnog krvarenja iz variksa jednjaka kod pacijenata sa portnom hipertenzijom. Evaluirano je 315 bolesnika sa cirozom jetre...
Surgical Outcome in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage - - - Hirurški ishod kod bolesnika sa spontanim supratentorijalnim intracerebralnim krvarenjem
The aim of the paper was to evaluate the surgical outcome in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) after surgical intervention, in respect to the initial clinical conditions, age, sex, h...