Nicotine-induced resistance of non-small cell lung cancer to treatment – possible mechanisms
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Cigarette smoking is the leading risk factor of lung cancer. Data from several clinical studies suggest that continuation of smoking during therapy of tobacco-related cancers is associated with lower response rates to chemotherapy and/or radiotherapy, and even with decreased survival. Although nicotine – an addictive component of tobacco – is not a carcinogen, it may influence cancer development and progression or effectiveness of anti-cancer therapy. Several in vitro and in vivo trials have evaluated the influence of nicotine on lung cancer cells. The best known mechanisms by which nicotine impacts cancer biology involve suppression of apoptosis induced by certain drugs or radiation, promotion of proliferation, angiogenesis, invasion and migration of cancer cells. This effect is mainly mediated by membranous nicotinic acetylcholine receptors whose stimulation leads to sustained activation of such intracellular pathways as PI3K/Akt/mTOR, RAS/RAF/MEK/ERK and JAK/STAT, induction of NF-κB activity, enhanced transcription of mitogenic promoters, inhibition of the mitochondrial death pathway or stimulation of pro-angiogenic factors. We herein summarize the mechanisms underlying nicotine’s influence on biology of lung cancer cells and the effectiveness of anti-cancer therapy.
Authors and Affiliations
Rafał Czyżykowski, Joanna Połowinczak-Przybyłek, Piotr Potemski
Keywords
Related Articles
- EP ID EP220758
- DOI -
- Views 136
- Downloads 0
Anaphylactic reactions to low-molecular weight chemicals
Low-molecular weight chemicals (haptens) include a large group of chemical compounds occurring in work environment, items of everyday use (cleaning products, clothing, footwear, gloves, furniture), jewelry (earrings, bra...
Kiedy obrona staje się niebezpieczna – czynnik transkrypcyjny Nrf2 a nowotwory
The transcription factor Nrf2 controls the expression of genes encoding cytoprotective enzymes and proteins. Its activation is related to conformational changes in the inhibitory protein Keap1 and/or Nrf2 phosphorylation...
Mechanizm włóknienia wątroby – rola komórek gwiaździstych, stresu oksydacyjnego i nitrozacyjnego
Włóknienie wątroby jest długotrwałym i złożonym procesem patologicznym, który występuje u pacjentów z przewlekłymi chorobami tego narządu niezależnie od ich etiologii. Najczęstszą patologią prowadzącą do włóknienia miąż...
Sprzężone dieny kwasu linolowego jako potencjalny czynnik prewencyjny w profilaktyce nowotworów piersi
Nowotwory złośliwe są drugą z najczęstszych przyczyn zgonów w Polsce, zarówno wśród kobiet, jak i wśród mężczyzn, a rak piersi zajmuje wśród nich pierwsze miejsce spośród zachorowań diagnozowanych u kobiet. W 2008 r. roz...
TGF-β1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study
Introduction: The aim was to assess the usefulness of TGF-β1 and elastase in the evaluation of activity of ulcerative colitis (UC) and Crohn’s disease (CD).Material and Methods: 32 patients diagnosed with UC, 31 with CD...