Notochordal cell: a new option for biological treatment of intervertebral disc degeneration?
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 6
Abstract
Intervertebral disc degeneration ( IDD ) is an important pathological basis of spinal degenerative diseases, which can cause complications such as intervertebral disc herniation, spinal canal stenosis and degenerative spinal deformity, seriously affecting human health and quality of life. In the early development of human intervertebral disc, there are large vesicle-rich notochordal cells and small vesicle-free nucleus pulposus cells. However, notochordal cells gradually disappear with aging, and at the same time early IDD begins to appear. Studies have shown that notochordal cells can maintain the normal physiological function of intervertebral disc by protecting nucleus pulposus cells. Meanwhile, notochordal cells can also inhibit vascular nerve infiltration and maintain the homeostasis of the intervertebral disc. In addition, notochordal cells can induce phenotypic differentiation of stem cells into nucleus pulposus cells. However, the above related mechanisms are still in the early stage, and the important role of notochordal cells in the intervertebral disc has not been fully elucidated. Therefore, it might be of great significance to further study the mechanism and related pathways of notochordal cells in regulating the normal function of intervertebral disc and explore the biological treatment of IDD.
Authors and Affiliations
SUN Zhen, DUAN Wei, CHANG Le, ZHAO Xin, XU Benchi, LUO Zhuojing, YE Zhengxu
Keywords
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