One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives
Journal Title: Asian Journal of Green Chemistry - Year 2018, Vol 2, Issue 4
Abstract
A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.
Authors and Affiliations
Ramin Javahershenas, Jabbar Khalafy
Keywords
Related Articles
- EP ID EP468809
- DOI 10.22034/ajgc.2018.62714
- Views 90
- Downloads 0
Synthesis, characterization, and thermal degradation of Cu (II) surfactants for sustainable green chemistry
The Cu (II) surfactantsof stearic and palmitic acids were synthesized which are greenish blue in colour and chosen for thermogravimetric and derivative thermal analysis. Their structure has been confirmed by elemental a...
Removal of ammonium ions from aqueous solution using hydroxy-sodalite zeolite
In this research study, the removal of ammonium ions from aqueous solution by hydroxy-sodalite (HS) was evaluated. The effects of the contact time, pH, initial concentration, adsorbent dose, and the presence of other com...
Bioactive principle loaded gold nanoparticles as potent anti-melanoma agent: green synthesis, characterization, and in vitro bioefficacy
The present communication warrants the presence of significant anti-melanoma bioefficacy in the native bark ethanolic extract (65.15%) of the plant Madhuca longifolia. A family of seven flavonoids has been ascertained in...
One-pot synthesis of spirooxindole derivatives catalyzed by ZnFe2O as a magnetic nanoparticles
ZnFe2O4 as a novel nanoparticle was prepared and characterized using x-ray diffraction (XRD) analysis, energy dispersive x-ray (EDX), vibrating sample magnetometry (VSM), and fourier-transform infrared (FTIR) spectra. Th...
Design and synthesis of two steroid derivatives from 2-nitroestrone and theoretical evaluation of their interaction with BRCA-1
Several compounds have been prepared to treatment of breast cancer; however, some of these drugs may produce some side effects. The aim of this study is to synthesize two new steroid derivatives (Compounds 7 or 8) to eva...