Optimization of fast dissolving aceclofenac tablets using factorial design

Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5

Abstract

The Aceclofenac is available in tablets dosage form and is yet not official in any pharmacopoeia except B.P. Aceclofenac is practically insoluble in water and peak blood level rechease between 1.25 to 3 hrs after oral administration. It is practically insoluble in aqueous fluids. The rate and extent of dissolution of the drug from any solid dosage form determines the rate and extent of absorption of the drug. Present work was undertaken to study the effect of variables on the characteristics of fast dissolving tablets of aceclofenac utilizing the factorial design. Solid dispersion containing aceclofenac and carrier in the proportion of 1:1, 1:2, 1:3, and 1:4 were prepared by either melt solvent or solvent evaporation method. A 32 full factorial design was adapted to optimize the variables6. Amount of crospovidone (X1) and amount of mannitol (X2) were selected as independent variables. In vitro dissolution study of tablets were conducted using USP dissolution apparatus II (model TDT-06T, Electolab) at 50 rpm, using phosphate buffer pH 6.8 as a dissolution media9, 10 maintaining at 37 ± 0.5 0 C. Sample were withdrawn at various time intervals, filtered through a whattmen filter paper, diluted and assayed at 275 nm using UV/ Vis double beam spectrometer. Solid dispersion of drug with mannitol was prepared by melt solvent method. The formulated tablets were characterized for various parameters like hardness, friability, disintegration, wetting and in vitro dissolution.

Authors and Affiliations

Prabhuling VR, PK kulkarni, Srikrihna R. M, Niraj kumar, Nansri Saha Ghosh, Soumik Ghosh

Keywords

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  • EP ID EP221979
  • DOI -
  • Views 130
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How To Cite

Prabhuling VR, PK kulkarni, Srikrihna R. M, Niraj kumar, Nansri Saha Ghosh, Soumik Ghosh (2011). Optimization of fast dissolving aceclofenac tablets using factorial design. Indo American Journal of Pharmaceutical Research, 1(5), 452-462. https://europub.co.uk./articles/-A-221979