Synthesis and Antimicrobial Evaluation of some novel 4-[4-(3-chloro-2oxo-4- substituted-phenylazetidin-1-yl)phenylamino]-1,2-dihydro-2,3-dimethyl-1- phenylpyrazole-5-one
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
A series of eight novel 2-Azetidinones (4a-h) have been synthesized by cyclocondensation of various Schiff bases of 4-[(4-aminophenyl)amino]- 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one with chloroacetyl chloride in presences of triethylamine. Various Schiff bases were synthesized by condensation of 4-[(4-aminophenyl)amino]-1,5-dimethyl-2- phenyl-1,2-dihydro-3H-pyrazol-3-one with various arylaldehydes (3a-h). The synthesized compounds (4a-h) were screened for their antibacterial activity gainst six microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Grampositive), Salmonella typhi (Gram negative) Escherichia coli (Gram negative) and fungal strain Aspergilius niger & Candida Albicans. They were found to exhibit good to moderate antibacterial activity. Among the eight derivative comp no-4e show the good activity.The structures were confirmed by IR, 1H- NMR and Mass spectral data.
Authors and Affiliations
Ajay Kr Yadav, Indu Shukla, Chhaya R Sahu, S. R. Sahu
Keywords
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