Synthesis and Antimicrobial Evaluation of some novel 4-[4-(3-chloro-2oxo-4- substituted-phenylazetidin-1-yl)phenylamino]-1,2-dihydro-2,3-dimethyl-1- phenylpyrazole-5-one
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
A series of eight novel 2-Azetidinones (4a-h) have been synthesized by cyclocondensation of various Schiff bases of 4-[(4-aminophenyl)amino]- 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one with chloroacetyl chloride in presences of triethylamine. Various Schiff bases were synthesized by condensation of 4-[(4-aminophenyl)amino]-1,5-dimethyl-2- phenyl-1,2-dihydro-3H-pyrazol-3-one with various arylaldehydes (3a-h). The synthesized compounds (4a-h) were screened for their antibacterial activity gainst six microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Grampositive), Salmonella typhi (Gram negative) Escherichia coli (Gram negative) and fungal strain Aspergilius niger & Candida Albicans. They were found to exhibit good to moderate antibacterial activity. Among the eight derivative comp no-4e show the good activity.The structures were confirmed by IR, 1H- NMR and Mass spectral data.
Authors and Affiliations
Ajay Kr Yadav, Indu Shukla, Chhaya R Sahu, S. R. Sahu
Keywords
Related Articles
- EP ID EP222208
- DOI -
- Views 94
- Downloads 0
UV-VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF ASSAY OF BENIDIPINE HYDROCHLORIDE TABLET FORMULATION
Abstract Simple, rapid, sensitive, precise and specific UV spectrophotometric method for the determination of Benidipine HCl in bulk drug and pharmaceutical dosage form were developed and validated. In this method soluti...
DRUG DELIVERY BY VIRUS LIKE PARTICLES
The drug delivery system described here is based on a virus like particle consisting of the recombinant expressed major capsid protein of Polyomavirus, VP1. Polyoma, a murine virus belonging to the Papovaviridae, forms a...
SIO2.CAA: AN EFFICIENT CATALYST FOR ONE POT SYNTHESIS OF 4,6- DIARYLPYRIMIDINE- 2(1H)-ONES OR THIONES
Abstract An efficient method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones or thiones by using SiO2.CAA. The condensation of acetophenone, aldehydes and urea or thiourea in the presence of silica supported catalyst...
PREPARATION AND EVALUATION OF HERBAL TOOTH POWDER COMPOSED OF HERBAL DRUGS WITH ANTIMICROBIAL SCREENING
The medicinal plant clove is famous for its dental analgeic potential in the herbal world is concerned. Apart from this, the ginger, asafoetida, amla, ajowan, pepper, neem bark, acacia bark, alum, mentha leaf and mustard...
IMPACT OF CLINICAL PHARMACIST MEDIATED CARE IN DIABETES MELLITUS - A NEW COMMUNITY BASED MODEL OF CARE
Abstract AIMS: The main Aim of the study is to evaluate the impact of clinical pharmacist care in improving glycemic control, HRQOL, medication adherence in type 2 Diabetes mellitus patients. METHODS: The study is conduc...