Oral flunarizine versus oral amitriptyline in migraine prophylaxis – A prospective open label study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2019, Vol 5, Issue 4
Abstract
Objectives To compare the effectiveness and tolerability of flunarizine and amitriptyline in migraine prophylaxis Also to assess the disability associated with migraine using Migraine Disability Assessment Test MIDAS and Headache Impact Test6 HIT6 questionnairesMaterials and Methods The study was a prospective observational openlabel comparative study conducted for six months among migraine patients attending Tertiary Care Hospital Mandya Patients were prescribed either Amitriptyline 25 mg or flunarizine 10 mg OD for three months Effectiveness was assessed by the number of episodes of migraine attacks pain severity score on Visual Analogue Scale VAS tolerability of adverse reactions reported and disability assessed using MIDAS and HIT6 questionnairesResults Out of 103 patients 55 were prescribed Amitriptyline and 48 patients flunarizine 495 of patients were between 18 to 30 years of age At the end of three months of treatment the frequency and severity of headaches decreased from baseline in both the groups The overall percentage of responders with 50 reduction from baseline in number of migraine episodes and pain severity together were 673 and 50 in amitriptyline and flunarizine groups respectively There was reduction in MIDAS and HIT6 scores in both groups without significant difference between the groups Both the drugs were well tolerated with most common adverse effects being dry mouth somnolence and constipationConclusion Both amitriptyline and flunarizine are effective in prophylaxis of migraine with significant reduction in number of episodes and severity of headache from baseline to end of treatment However Amitriptyline had a higher overall responder rate when compared to Flunarizine with similar tolerability profileKeywords Migraine prophylaxis Amitriptyline Flunarizine MIDAS HIT6
Authors and Affiliations
Nagabushan H, Bhavani V, Bhagyavathi H. D
Keywords
Related Articles
- EP ID EP478569
- DOI 10.18231/2393-9087.2018.0037
- Views 93
- Downloads 0
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