Ototoxicity Probably Due To Isoniazid in a Patient Undergoing Hemodialysis
Journal Title: Journal of Neurological Sciences-Turkish - Year 2008, Vol 25, Issue 1
Abstract
Patients with end-stage renal failure (ESRF) have a high incidence of tuberculosis. Antituberculosis drug-induced ototoxicity may sometimes be a problem in these group of patients. Streptomycin is an antituberculosis drug with well-known ototoxic side effects. However, ototoxicity with combinations not including streptomycin has been reported only in a report in 7 of 42 ESRF patients undergoing hemodialysis and isoniazid has been suggested as a probable responsible drug which has well-known neurotoxic side effects. Here, we presented a 78- year-old man developed hearing loss who was on hemodialysis program and taking antituberculosis drug combination therapy including not streptomycin, but isoniazid, and the probable role of isoniazid in ototoxicity was discussed.
Authors and Affiliations
Deniz YERDELEN, Meliha TAN
Keywords
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