Overview of Drug Resistant Mycobacterium tuberculosis

Abstract

MDR-TB is a global occurrence that poses a serious threat. Tuberculosis (TB) is still the leading cause of death from a single and curable infectious disease. It is the second-most common cause of death from infectious disease (after those due to HIV/AIDS). Its situation is worsened by the presence of multidrug resistant (MDR) strains of M. tuberculosis. In ancient time, it was considered as a curse. Tuberculosis started to reemerge in the early 1990s. The completion of the first whole genome sequence of M. tuberculosis was in 1998. Multi drug resistant (MDR)-TB is caused by strains of M. tuberculosis that resistant to at least rifampicin and isoniazid. Worldwide India is the country with the highest burden of both TB and MDR-TB. Isolation of MTB on solid media followed by subsequent DST on solid media is easy to perform in the lab. They are time-consuming classical laboratory tests methods. So, molecular method is preferable to detect MTB. Different types of tool are available to detect MDR-TB, XDR-TB. Now-a-days, there are three major commercial alternatives available and they are: GeneXpert, line probe assays (LPA) and Nucleic acid amplification tests (NAAT). Treatment takes too long, many patients are unable to tolerate the combination, and there is a growing threat from multidrug-resistant (MDR) and extremely drug-resistant (XDR)-TB. Reliable and timely detection of drug-resistant TB is needed.

Authors and Affiliations

Anurag Rai, Taiyaba khan

Keywords

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  • EP ID EP670910
  • DOI 10.21276/ijlssr.2018.4.3.9
  • Views 122
  • Downloads 0

How To Cite

Anurag Rai, Taiyaba khan (2018). Overview of Drug Resistant Mycobacterium tuberculosis. SSR Institute of International Journal of Life Sciences (SSR-IIJLS), 4(3), 1795-1800. https://europub.co.uk./articles/-A-670910