Paraneoplastic syndromes in daily clinical practice
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 8, Issue 2
Abstract
Paraneoplastic syndromes consist of disorders that accompany benign and malignant tumours, but are not directly related to mass effects or invasion by the primary tumour or its metastases. The pathophysiology of mostly paraneoplastic syndromes is not well known. The usual mechanism of their development is the aberrant production of substances (protein hormones, hormone precursors or hormone-like substances) by tumour tissue or autoimmune disorder. The neurological paraneoplastic syndromes are autoimmune disorders that can affect almost any part of the nervous system. The endocrine paraneoplastic syndromes are often certain clinical syndromes like paraneoplastic hypercalcaemia or the aberrant production of hormones by cancers. Many haematologic conditions, including anaemia, leucocytosis, thrombocytopenia or thrombocytosis, coagulapathy have been reported in association with cancer. Also paraneoplastic rheumatic syndromes have been reported in association of cancer. Skin can be involved in cancer in different ways: by metastases, as a part of a genetic disorder with a cutaneous component in which there is an inherited predisposition to the later development of malignancy, as a part of an acquired syndrome due to the toxicity of a carcinogen that induces malignant change and accompanying skin changes, as a consequence of immunosuppression, or by the development of specific lesions that occur as a paraneoplastic syndromes The most frequently diagnosed dermatologic conditions include acrokeratosis paraneoplastica, Sweet’s syndrome and paraneoplastic pemphigus. The purpose of this article is to describe the most popular in internal clinical practice neurologic, endocrine, aematologic, rheumatologic and dermatologic paraneoplastic syndromes associated with cancer.
Authors and Affiliations
Monika Wójtowicz, Agata Rękas-Wójcik, Aleksandra Lipa, Andrzej Prystupa, Grzegorz Dzida
Keywords
Related Articles
- EP ID EP58815
- DOI -
- Views 149
- Downloads 0
Professional communication competences of nurses
Introduction: Dissonance between the high ‘technical’ professionalism of nurses and the relatively low level of patient satisfaction with care received is a phenomenon observed in many countries. Many studies show that i...
Raised concentrations of lipid peroxidation products (LPO) in pregnant women with impaired glucose tolerance
introduction. Lipid peroxidation (LPO) results from oxidative damage to membrane lipids. Whereas LPO rises in normal pregnancy, the effect of gestational diabetes mellitus (GDM) on this process has not been clearly defin...
Selected environmental aspects of the introduction into the polish market of exotic wood species on the example of caviuna ([i]Machaerium scleroxylon[/i] Tul.)
The chemical and elemental composition of caviuna wood was determined. The elemental composition of the examined wood was similar to the elemental composition of the deciduous tree species of the temperate zone except th...
Studies of farmers’ annual exposure to whole body vibration on selected family farms of mixed production profile[sup][/sup]
The objective of the study was to recognize and evaluate the annual exposure of private farmers to whole body mechanical vibration on selected family farms of mixed production profile (plant-animal). The scope of study c...
Limited usefulness of the test of spontaneous growth hormone (GH) nocturnal secretion as a screening procedure in diagnosing GH deficiency in children with short stature
[b]introduction and objective[/b]. In Poland, the assessment of nocturnal GH secretion has gained the status of screening test; however, this procedure is not included in international recommendations. The aim of the stu...