Pathogenetic Mechanisms of Brain Damage at Neuroinfections in Children
Journal Title: Актуальна інфектологія - Year 2014, Vol 5, Issue 4
Abstract
The article presents the value of neuron-specific enolase and autoantibodies to glutamate receptor NR2A subunits as markers of ischemia and neurodestruction at acute meningitis in children. Presence of autoantibodies to the decay products of NMDA glutamate receptors, that are damaged in ischemia, indicates involvement of autoimmune component in the pathogenesis of neuroinfection development in children. It is shown that the level of neuron-specific enolase in the blood at acute meningitis may act as a marker of the depth of nerve tissue destruction and encephalitis development, as well as effectiveness and duration of neuroprotective therapy.
Authors and Affiliations
L. V. Pypa, R. V. Svistilnyk, T. V. Serdiuk, Yu. M. Lysytsia
Keywords
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