PATTERN OF ADVERSE CUTANEOUS DRUG REACTIONS IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 89
Abstract
BACKGROUND An adverse cutaneous drug reaction is an undesirable change in structure and function of skin, its appendages or mucous membrane due to drugs.1 The main aim of this study is to detect the pattern of adverse cutaneous drug reaction in a tertiary care hospital. MATERIALS AND METHODS This hospital-based observational study was performed in a tertiary care hospital, SRMC, Chennai, for 1 year from June 2013 to June 2014. For each case, data regarding age and sex of the patient, detailed clinical history, past history and comorbidities, name of suspected drugs, duration between drug intake and onset of reaction, morphology of drug eruption, associated mucosal or systemic involvement were carefully analysed. Different types of drug reactions manifested in the study population were studied and the offending drugs were noted. RESULTS During the one year study period, 30 patients have attended the dermatology outpatient department with cutaneous adverse drug reaction. The mean age of our patients with adverse drug reactions was 57 years. The male-to-female ratio was 7:3. The commonest reaction pattern observed was exfoliative dermatitis (28%), fixed drug eruption (28%) followed by toxic epidermal necrolysis (10%), Stevens-Johnson syndrome (10%), Bullous fixed drug eruption (10%) and Urticaria (6%). Commonest drugs producing reactions were Amoxicillin (23%), Paracetamol (16%), Carbamazepine (10 %) and Phenytoin (10%). CONCLUSION After a cutaneous drug eruption has been diagnosed and treated, clear information must be provided to the patient regarding his/her drug rash. Early diagnosis and prompt withdrawal of the offending drug and administration of systemic steroids can be lifesaving in cutaneous adverse drug eruption.
Authors and Affiliations
Riswana Nasrin Nazeer Ahamed, Adikrishnan Swaminathan, Anuradha Priyadarshini, Manu Vidhya Harikumar, Krishnakanth Muralidharan, Murugan Sundaran, Sudha Rangarajan, Mahalakshmi Veeraraghavan
Keywords
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- EP ID EP277992
- DOI 10.14260/jemds/2017/1356
- Views 103
- Downloads 0
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