Peculiarities of the carbohydrate metabolism in patients with chronic obstructive pulmonary disease and concomitant chronic pancreatitis
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 1
Abstract
Background. Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality in the world. We can see a combination of chronic obstructive pulmonary disease with disorders of the digestive system, such as chronic pancreatitis, in clinical practice. The functional status of the pancreas plays a direct role in the development of the main components of the metabolic syndrome (hyperinsulinemia, insulin resistance with impaired glucose tolerance). Materials and methods. We have examined 90 patients with chronic obstructive pulmonary disease and chronic pancreatitis, and studied of carbohydrate metabolism, lipid peroxidation and the content of final metabolites of nitric oxide (nitrites/nitrates). Results. The study found an increase in the degree of insulin resistance and the development of oxidative stress. Comprehensive treatment of patients with chronic obstructive pulmonary disease and chronic pancreatitis, which included the administration of basic therapy and reduced glutathione, led to a decrease of the insulin resistance and the restoration of serum reduced glutathione. Conclusions. Decrease in the serum reduced glutathione and the increase of serum level of final metabolites of nitric oxide is accompanied by the increase of degree of insulin resistance.
Authors and Affiliations
O. O. Ursul
Keywords
Related Articles
- EP ID EP176199
- DOI 10.22141/2224-0721.13.1.2017.96760
- Views 85
- Downloads 0
The Dynamics of Iodine Deficiency Disorders in the Republic of Karakalpakstan Based on the Epidemiological Studies of 1998, 2004 and 2014
The article summarizes the results of monitoring for iodine deficiency disorders in Karakalpakstan from 1998 to 2014. In accordance with the WHO recommendations, there were assessed the following indicators: the prevalen...
The course of gastroduodenal bleedings in peptic ulcer patients with comorbid diabetes mellitus
Background. The prevalence of gastroduodenal ulcerative bleeding reaches 170 cases per 100,000 of the adult population, and the annual mortality due to them is 15 %. Comorbid diabetes mellitus (DM) is an independent risk...
Effects of vitamin D on pregnancy, fetal development and children’s health in the postnatal period
A high prevalence of vitamin D insufficiency and deficiency and its negative consequences for health is identified as the area of primary concern for scientists and clinicians worldwide. Observational studies confirm tha...
News of Practical Endocrinology Following the Results of the Congress of the European Society of Endocrinology 2016
The review was made of the reports submitted in the framework of the event from the series «Endocrinology Board», held on November 23, 2016 in Kyiv, Ukraine.
Prevalence of Growth Hormone Deficiency in Adults with Pituitary Adenomas
In this article, the authors analyzed the data of patients with pituitary tumors, of which 35 (87.5 %) suffered from growth hormone deficiency (GHD) in adults with neuroendocrine complications. Specific to GHD is a group...