Personalized Medicine Digoxin Theraphy in Individuals with MDR Gene Polymorphism
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
Digoxin is one of digitalis drugs. Wider applicability to heart failure and arrhythmias (supraventricular) requires fairly strict scrutiny because of its narrow therapeutic index. Digoxin is a substrate of P-glycoprotein (P-gp) encoded by multi drugs resistance-1 (MDR1). MDR-1 gen located on chromosome 7q21.1. This gene contains 28 exons that encoded a protein of 1280 amino acids. This gene plays an important role in the absorption, distribution and elimination of many drugs. MDR1C3435T polymorphism occurs in exon 26. There are three types of MDR1C3435T gene namely MDR1C3435T CC, MDR1C3435T CT and MDR1C3435T TT. These polymorphisms will affect to the formation of P-gp and consequently to change the kinetic profile of digoxin. The change of kinetic profile causes changes in the digoxin blood levels. The method used in this review is data search based on pubmed, medline, and embase with keywords MDR and digoxin. There are several different studies of the influence of polymorphisms MDR1C3435T on blood digoxin levels. Increased levels of digoxin in the blood due to polymorphism of MDR1C3435T will be at risk of digitalis intoxication. Long-term digoxin treatment or large dose should consider the patient’s genetic profile. Distribution of polymorphism of MDR1C3435T in Javanese population is approximately TT (0,10), CT (0,52), and CC(0, 38).
Authors and Affiliations
Em Sutrisna
Keywords
Related Articles
- EP ID EP355554
- DOI 10.15416/ijcp.2015.4.2.113
- Views 113
- Downloads 0
Potential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung
Polypharmacy prescription very commonly occurs on prescribing the outpatient and inpatient in every health facility. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in...
Role of Leadership and Employee Engagement towards Individual Performance of Pharmacy Employees
Employees dissatisfaction to the head of the hospital pharmacy will decrease employees performance and unsatisfied customers. To solve the problems, employees should be based on performance as customer expectations in pr...
Personalized Medicine Digoxin Theraphy in Individuals with MDR Gene Polymorphism
Digoxin is one of digitalis drugs. Wider applicability to heart failure and arrhythmias (supraventricular) requires fairly strict scrutiny because of its narrow therapeutic index. Digoxin is a substrate of P-glycoprotei...
The Effect of Astaxanthin and Regular Training on Dynamic Pattern of Oxidative Stress on Male under Strenuous Exercise
Strenuous physical activity will induce higher Reactive Oxygen Species (ROS) level in human body that can be measured by serum malondialdehyde (MDA) level. Malondialdehyde is product of lipid peroxidation process that de...
Relationship between Obesity and Hypertriglyceridemia on Fatty Liver in Patients at Makassar
Fatty liver is caused by a failure of normal hepatic fat metabolism due to a dysfunction of either within the hepatocytes. The degree of fatty liver is correlating to the increase of body weight. The aim of this study...