Pharmacognostical, phyotochemical and toxicity profile of flower of Ishwari - Aristolochia indica Linn
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 3
Abstract
Aristolochia indica Linn. (Aristolochiaceae) is popularly known as Ishwari and Nakuli in Samhitha Granthas. Ishwari is used in different forms for condition like sheethajwara, sarpavisha, vrana, ekangashopha, unmada, apasmara etc. One of methods of plant wealth conservation is by promoting use of plant parts other than root in therapeutics. Flower is one such plant part which can be studied as substitute for therapeutic benefits of root. Prior to such trials such proposed substitutes must undergo various pharmacognostical, analytical, toxicological and pharmacological studies. Microscopy, phtochemical examination, HPTLC and acute toxicity studies of A. indica flowers were performed flowing standard procedure. Powder microscopy revealed some specific characters for its identification. Phytochemical study showed presence of steroid, carbohydrate, flavonoids and saponins. HPTLC fingerprint of the flowers was derived. On toxicity evaluation no adverse effects were observed on administration of powder of flower orally in rat. These diagnostic features can be used as a fingerprint for the identification and differentiation of their substitute and adulterants of the plant. As there is no toxicity up to 2000 mg/kg body weight, 1/10 of the dose i.e. 200 mg/kg can be considered as therapeutic dose for further studies on this drug.
Authors and Affiliations
Mohammed Faisal, Bairy Sridhar, KN Sunil Kumar, Sudhakara, Ravi M
Keywords
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