PHARMACOLOGICAL STUDIES OF CATHA EDULIS FORSK. ON ISOLATED ANIMALS TISSUES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
There is growing concern about the health hazard of chronic khat (Catha edulis forsk.) chewing and this research concentrates on the adverse effects of this abused plant including the gastrointestinal tract, reproductive, cardiovascular and muscular system. Extraction of Catha edulis leaves was done and the presence of cathine was confirmed with LC-MS-MS. Hence in this study, we exposed cathine-rich khat extract (KARF) to the vitro models of the three types of muscle tissues (cardiac, smooth and skeletal). This includes rabbit jejunums and aortas, rat fundus strips and uteri, frog rectus abdominal muscles and guinea pig ileum and atria. Acetylcholine (ACh), 5-hydroxytryptamine (5-HT), carbachol, isoprenaline, salbutamol, noradrenaline and histamine were used as positive controls. The current observations recommend that the vasoconstriction of noradrenaline on aorta ring strips was inhibited by the sympatholytic of KARF. KARF alone did not induce any cardio-pharmacological effects. However prior administration of KARF effects the myocardial increasing effects of only non-selective (isoprenaline) but not the selective beta2 adrenoreceptor (salbutamol) agonist on the atrium. Contractile response to carbachol, ACh and 5-HT were dose-dependently antagonized by preadministration of KARF. The spasmogenic effect of histamine on guinea pig ileum were observed to be antagonized by the KARF in a concentration dependent manner. These current findings on isolated animal tissues and organs after KARF administration should be a warning regarding the health hazards of khat chewing.
Authors and Affiliations
Dr. Nasreddin Osman Sabir
Keywords
Related Articles
- EP ID EP620010
- DOI -
- Views 143
- Downloads 0
TWO YEARS FOLLOW UP – OCTOGENARIAN GERIATRIC FEMALE WITH POSTURAL DEFORMITIES OF THE SPINE TREATED BY PHYSIOTHERAPY
Geriatric female living independently was treated in this study for postural deformities of the spine. Muscular imbalance along with obesity can influence posture of the neck and lumbar spine. Complaints with inability t...
POOR ADHERENCE TO ANTIDIABETIC MEDICATIONS IN PATIENTS WITH DIABETES AT MADINA, SAUDI ARABIA: THE ROLL OF DIABETES RELATED EMOTIONAL DISTRESS
Background: Diabetes mellitus is a chronic disease that significantly grows globally. It is a major cause of mortality and morbidity and so, excellent control for diabetes by medication is strictly advised. Patients may...
THE BIOLOGICAL EFFECT OF B-SITOSTEROL ON HEPATOMA CELL HEPG2 TRANSFECTED WITH HBX GENE
Hepatitis B virus (HBV) infection is endemic disease in many areas around the world and is considered as one of the risk factor for hepatocellular carcinoma .The latter is the fifth leading cause of death and rapidly inc...
OXIDANT, ANTIOXIDANTS AND SOME BIOCHEMICAL PARAMETERS IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY
This work was conducted to study the role of oxidative stress and some biochemical parameters in type 2 diabetic nephropathy patients. Fifteen type 2 diabetic nephropathy and ten type 2 diabetic patients (at the age 57-6...
APHRODISIAC AND FERTILITY ENHANCING ACTIONS OF ‘KUNU AYA’ (A BEVERAGE BLEND DEVELOPED FROM CYPERUS ESCULENTUS, PHOENIX DACTYLIFERA AND COCOS NUCIFERA) VIA TESTOSTERONE- BOOSTING, ANXIOLYSIS AND INHIBITION OF KEY ENZYMES ASSOCIATED WITH ERECTILE PROCESS
Sexual dysfunctions occur at a point in an adult‟s lifetime. To address this problem a number of therapeutic strategies have been developed, some of which are inadequate and/or plagued with side effects. Consequently, al...