Physico –Chemical Characterization & In Vitro Dissolution behavior of Telmisartan utilizing solid dispersion by PEG-6000
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 5
Abstract
This article investigates enhancement Solubility is an important physicochemical factor affecting absorption of drug and it’s therapeutic of the dissolution profile of Telmisartan effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. Telmisartan is an angiotensin II receptor antagonist which is used in the prevention and treatment of Hypertension. One of the major problems with it is its low solubility in biological fluids, which results into poor bioavailability after oral administration (~42%) and late onset of action poorly soluble drug, Telmisartan. Solid dispersions were prepared using Polyethylene glycol-6000 (PEG-6000) Telmisartan solid dispersions were prepared in 1:1, ratios of the drug to polymer ratio & it’s applied to different techniques of Solid dispersion (by weight) like using Physical mixing, Kneading method solvent evaporation method & fusion method. The formulations were characterized for solubility parameters; drug content studies drug release studies and drug-polymer interactions by using FTIR spectrum & X-RD. Formulation containing 1:1 ratio of drug: PEG-6000 (Kneading method) show best release with cumulative release of 45.53% as compared to 98.37% for the pure drug. The interaction studies showed no interaction between the drug and polymer, it was concluded that PEG -6000 as carrier can be very well utilize to improve the solubility of poorly soluble drugs.
Authors and Affiliations
Rakesh singh, Dr. D. A. Jain
Keywords
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