ПОКАЗАТЕЛИ ЛЕГОЧНОЙ МИТОХОНДРИАЛЬНОЙ ФУНКЦИИ ПРИ АБСОЛЮТНОЙ ИНСУЛИНОВОЙ НЕДОСТАТОЧНОСТИ
Journal Title: World Science - Year 2016, Vol 3, Issue 10
Abstract
Significance for structural and functional state of cells in the respiratory system in diabetes mellitus perform metabolic processes owned energy supply, carried out by mitochondria. By biochemical manifestations of energy exchange include an increase in concentration of lactate and mitochondrial marker enzyme ‒ succinate dehydrogenase (SDH). The aim of the study was the cytochemical analysis of mitochondrial function in patients with absolute insulin deficiency. Cytochemical analysis was based on a study of the degree of activity of the major enzymes catalyzing the aerobic and anaerobic cells exchanges in peripheral blood lymphocytes - SDH and LDH, with visual and computer morphometry using the program «Videotest 4.0». The substrate for the study of cellular factors of the respiratory system was the bronchoalveolar secret obtained during diagnostic bronchoscopy according to standard procedure. In the study of bronchoalveolar lavage determined reduction of quality indicators, the functional activity of cells in the bronchoalveolar space of type 1 diabetes. As a result, cytochemical investigation detected inhibition of cellular metabolism of lymphocytes in the form of lower levels of SDH and LDH activity in patients with type 1 diabetes when compared with those in the control group by 1.6 and 2.1 times, respectively, with p <0.001. The level of activity of mitochondrial dehydrogenases influenced the viability of the cellular elements of the respiratory system, and was influenced by the level of hyperglycemia. A result of research was found that in hyperglycemic conditions, the level of lymphocyte dehydrogenase activity may serve as a diagnostic criterion of the functional state of mitochondria and an indicator of energy supply airways and lung tissue as a whole.
Authors and Affiliations
О. А. Пивоварова, Б. Н. Маньковский
Keywords
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