PRE-EXPOSURE PROPHYLAXIS (PrEP) AS HIV PREVENTION STRATEGY AND PUBLIC HEALTH IMPLICATIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 4
Abstract
As the rate of AIDS-related mortality continues to decrease due to advanced combination antiretroviral therapies available, many recent efforts have been made to stop new infections. While there are still ongoing research efforts on HIV vaccine development, Truvada® for pre-exposure prophylaxis (PrEP) is available to general public as an HIV prevention strategy. PrEP specifically targets populations at-risk including gay men, men-who-have-sex-with-men(MSM), and heterosexual serodiscordant couples. A recent study of PrEP utilization reported an extraordinary slow uptake of PrEP; it suggests a need to evaluate current PrEP roll-out. This review explores potential causes of the current slow uptake phenomena. These include common concerns among PrEP providers and populations at-risk; long-term side effects, PrEP adherence, fear of drug-resistance, and potential rise of risky sexual behaviors. Previous PrEP randomized clinical trials (RCTs) showed its effectiveness but did not recognize its potential barriers outside clinical settings. Implementation of PrEP in a population-level should therefore include comprehensive counseling programs to support medication-adherence, and future research must carefully monitor current PrEP users and address potential pitfalls to maximize its protective benefits.
Authors and Affiliations
Hyungwoo Sean , Young Ga , Jongwha Chang
Keywords
Related Articles
- EP ID EP132541
- DOI 10.7897/2230-8407.06450
- Views 93
- Downloads 0
TOXICOLOGICAL STUDIES OF THE AQUEOUS EXTRACT FROM BRILLANTAISIA VOGELIANA (NÉES) BENTH. (ACANTHACEAE)
Brillantaisia vogeliana (Acanthaceae) is used in folk medicine in the West region of Cameroon to manage obesity. In this study, we investigated the toxic effect of the aqueous extract of B.v. in rats. Three doses of...
FORMULATION AND EVALUATION OF AMLODIPINE TRANSDERMAL PATCHES USING ETHYL CELLULOSE
The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as ethyl cellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by usin...
THERAPEUTIC SIGNIFICANCE OF QUINOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Microbial infections are one of the leading diseases which are responsible for millions of deaths every year because of lack of effective antimicrobial therapy and this situation becomes more complicated because of micro...
PHYTOCHEMICAL SCREENING, FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CEIBA PENTANDRA
The seed of Ceiba pentandra collected from the rural area of Shirur, Pune district, were dried, milled and extracted with ether, ethanol and water. Phytochemical screening was carried out according to standard procedures...
EVALUATION OF ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF CINNAMOMUM TAMALA LINN LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The main objective of this study was to focus on the anti-diabetic activity of Cinnamomum tamala Linn, with special reference to its curative and protective role in streptozotocin- induced diabetic animal model. Attempts...