Preparation and evaluation of osmotic controlled release Verapamil (180 mg) tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 6
Abstract
Controlled release tablets of verapamil based on osmotic technology was developed and evaluated. Verapamil half life2.8-7.4 Hrs, it is short acting drug, developed formulation provide the prolong controlled release formulations. Verapamil was chosen as a model drug with an aim to develop a controlled release system for 24 h. The developed formulation advantage of less steps of manufacturing procedure and no need of laser drilling, verapamil 180 mg core formulation was prepared using with osmogens and coating with different coating materials. The optimize film former (cellulose acetate): mechanical drilling used for pour formation. Effect of different formulation variables namely effect of osmogens. Pour size of membrane are studied. Drug release rate of verapamil directly proportional to pour size in membrane. The optimum drug release at the pour size 800µm for the optimized formulation. All excipients and polymers use in optimized formulation were found to be compatible with the drug, and compatibility study confirmed by FT-IR spectroscopy. Drug release from the optimized formulation independent not depends on concentration. The drug release mechanism follows mixed mechanism combination of diffusion and erosion mechanism. Optimized formulation of verapamil osmotic controlled release formulation compared with marketed formulation Covera HS. Drug release profile of optimized formulation amount of drug release Superior than the marketed formulation. Optimized formulation (F3) was greater than the marketed formulation.
Authors and Affiliations
Ismail Shaik, Harish G, B. Pragati Kumar, T. Abhilash
Keywords
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