Preparation and In Vitro, In Vivo Evaluation of Clarithromycin Microcapsules
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2011, Vol 2, Issue 1
Abstract
PURPOSE: To develop and validate a method to prepare clarithromycin (CLM) microcapsules to mask the bitter taste and provide effective treatment, and evaluate the quality of microcapsules in detail, especially the in vitro and in vivo pharmacokinetics behavior. METHODS: CLM microcapsules were prepared using ethyl cellulose as matrix material by an emulsion solvent diffusion method. The physicochemical property, in vitro release study, sensory test and stability test were evaluated. Self-made CLM dry suspension or conventional tablets containing 250 mg of CLM were orally administered with 250 mL of water. The plasma concentration was determined and the pharmacokinetic parameters were calculated by non-compartmental methods. RESULTS: Stable microcapsules could be prepared using ethyl cellulose as matrix material. The quality evaluation of prepared microcapsules was qualified, and the pharmacokinetic parameters of dry suspensions and conventional tablets were as following. Cmax were 1.32±0.62 and 1.40±0.58 μg•ml-1; Tmax were 3.51±0.54 and 2.01±0.42 h; AUC were 7.65±2.54 and 7.12±2.10 μg•h•ml-1. CONCLUSION: The preparation method is easy and applicable. The self-made CLM dry suspension containing microcapsules sufficiently alleviate the bitterness of commercial CLM dry suspension, but not decrease the bioavailability and have better effect for delaying drug release in healthy volunteers.
Authors and Affiliations
Liandong Hu, Wei Liu, Li Li, Jiqiang Zhao, Xun Yang
Keywords
Related Articles
- EP ID EP97800
- DOI -
- Views 159
- Downloads 0
ANTIHYPERGLYCEMIC EFFECT OF ETHANOLIC EXTRACT AND FRACTIONS OF ANACARDIUM OCCIDENTALE L. STEM BARK IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The numbers of adults with diabetes in the world is estimated to rise 300 millions in the year 2025 and this leads to increasing search for better anti-diabetic drug. The effects of the ethanol extract (1.25g/kg) and fra...
CACO-2 CELL LINES IN DRUG DISCOVERY - AN UPDATED PERSPECTIVE
Cell lines are the invitro models used for the drug permeability studies in the preclinical and clinical phases of the drug discovery. Cell line models are simple and quick to use and avoids the usage of animal models fo...
A COMPARATIVE EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF THE BARK OF FICUS BENGALENSIS IN PLANTS OF DIFFERENT AGE
The medicinal plants have been selected for thorough studies from indigenous folk medicines, Ayurvedic, Unani and Siddha systems of medicines. The aim of this study deals with the comparative evaluation of anti-inflammat...
Antibacterial activity of Momordica charantia (Curcubitaceae) extracts and fractions
Momordica charantia L. belongs to the family Curcubitaceae and it is very common in many Brazilian regions. The plant is a liana with flowers and yellow fruits that present red seeds when are ripe. Popularly known as “me...
Evaluation of Anthelmintic Activity of Pistia stratiotes Linn.
The ethanolic extract of the plant Pistia stratiotes (Araceae) was investigated for activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic...