Preparation of Chitosan Nanoparticles and their In-vitro Characterization
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 2
Abstract
Background- Chitosan is a natural, biocompatible, biodegradable, nontoxic and easily available polymer that can be used to prepare nanoparticles. Chitosan nanoparticles can be widely used in pharmaceutical industries as an antimicrobial agent or as drug delivery vehicle. Objectives- Aim of the study was to prepare chitosan nanoparticles and characterize them. Methods: Chitosan nanoparticles were prepared by ionic gelation method and characterized by UV-Vis spectroscopy, FTIR (Fourier transform infrared spectroscopy), DLS (Dynamic Light Scattering) and Scanning electron microscopy (SEM). Results- The present study showed that chitosan nanoparticles were successfully prepared by ionic gelation method. The obtained chitosan nanoparticles were characterized and study revealed that they are stable spherical in shape. The size of chitosan nanoparticles (CSNPs) at selected concentration was 216 nm and zeta potential 50mV was done by zeta sizer Nano S (Malvern, UK). Conclusions- Chitosan nanoparticles were successfully prepared by ionic gelation method.
Authors and Affiliations
Megha Agarwal, Mukesh Kumar Agarwal, Nalini Shrivastav, Sarika Pandey, Ritu Das
Keywords
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- EP ID EP671167
- DOI 10.21276/ijlssr.2018.4.2.17
- Views 88
- Downloads 0
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