PRESENCE OF SEROTONERGIC 5HT4-TYPE RECEPTORS IN BROILER’S SMALL INTESTINE
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2
Abstract
The aim of the present study was to try to determine the possible distribution of 5-HT4 receptors in small intestine of broilers (duodenum, jejunum and ileum). The disturbances of bowel function are common in broilers and if we know that mentioned dysfunction cause great loss to the poultry industry, due to the high mortality, the results of our research could form the basis for the introduction of new drugs in the pharmacotherapy of this species. Investigation were carried out on isolated smooth muscle of the circular and longitudinal layer of the broilers small intestine (strip dimnesion 3-4 mm x 2 cm). The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations were recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotinin (nonselective 5-HT agonist), 2-Me-5HT (5-HT3 agonist) and Y-25130-hydrochloride (selective 5-HT3 antagonist). The sensitivity of the tissues to acetylcholine was tested before starting the experiments. The research established a presence of serotonergic 5HT3 type receptors within the smooth musculature of the small intestines of broilers (COBB 500). The 5HT3 type receptors were present in smooth muscles of duodenum, jejunum and ileum, especially in longitudinal smooth muscles since this layer reacted even to low serotonin concentration (10-6). In the light of these findings, we suggest that investigated substances may have considerable physiological and therapeutic implications in disturbed function of small intestine of broiler’s.
Authors and Affiliations
Katica Muhamed
Keywords
Related Articles
- EP ID EP635516
- DOI -
- Views 174
- Downloads 0
CHRONIC PROSTATITIS; SYMPTOMATOLOGY AND THE IMPACT ON THE QUALITY OF LIFE IN A SRI LANKAN POPULATION
Introduction: Chronic prostatitis/Chronic Pelvic Pain Syndrome affect men of all ethnicities and they experience considerable morbidity. Materials and Methods: This descriptive cross sectional study was conducted in the...
COMPARATIVE IN-VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF METFORMIN TABLETS MARKETED IN TRIPOLI-LIBYA
The availability of several brands of Metformin tablets in Libyan pharmacies today places health practitioners in a problem of generic substitution. The aim of the present study was the evaluation and comparison between...
DIPYRIDAMOLE ATTENUATES THE GASTRIC INJURY IN ADULT AND AGED FEMALE RATS
Age is one of the important factors that affect the drug effects. Gastric ulcer is a common disease especially in elderly. Patients, especially elderly, who are treated with anti-platelet drugs may be exposed to a risk o...
A STUDY OF COMPARATIVE ANALYSIS AMONG DNA CONTENT IN DRUPE, POME, HESPIRIDIUM, PEPO AND COMPLEX FRUITS
Genomic DNA extraction is an important aspect of plant molecular biological research. The objective of the study was to recommend the cheap and efficient genomic DNA extraction method for some economically important frui...
ENHANCEMENT OF MILD HYPERTHERMIA- INDUCED APOPTOTIC CELL DEATH BY AUTOPHAGY ALTERATION IN MYELOGENOUS LEUKEMIA CELL LINE M-NFS-60
The present study investigates the effect of autophagy alteration on the cytotoxicity of mild hyperthermia (41 ºC, 1 h) toward M-NFS-60; a myelogenous leukemia cell line. Autophagy was inhibited by 5 mM NH4Cl which halts...